PDBsum entry 4fea

Hydrolase/hydrolase inhibitor

PDB id: 4fea

Contents

Protein chains

170 a.a.

196 a.a.

Ligands

0TE ×2

PDB id:

4fea

Name:

Hydrolase/hydrolase inhibitor

Title:

Crystal structure of caspase-7 in complex with allosteric inhibitor

Structure:

Caspase-7. Chain: a, b. Fragment: p20/p10 catalytic domain (unp residues 57-303). Synonym: casp-7, apoptotic protease mch-3, cmh-1, ice-like apoptotic protease 3, ice-lap3. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: casp7, mch3. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

3.79Å R-factor: 0.242 R-free: 0.286

Authors:

V.Kabaleeswaran

Key ref:

T.Feldman et al. (2012). A class of allosteric caspase inhibitors identified by high-throughput screening. Mol Cell, 47, 585-595. PubMed id: 22795132

Date:

29-May-12 Release date: 01-Aug-12

Protein chain

P55210  (CASP7_HUMAN) -  Caspase-7 from Homo sapiens

Seq: 303 a.a.

Struc: 170 a.a.

Protein chain

P55210  (CASP7_HUMAN) -  Caspase-7 from Homo sapiens

Seq: 303 a.a.

Struc: 196 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.4.22.60 - caspase-7.

Mol Cell 47:585-595 (2012)

PubMed id: 22795132

A class of allosteric caspase inhibitors identified by high-throughput screening.

T.Feldman, V.Kabaleeswaran, S.B.Jang, C.Antczak, H.Djaballah, H.Wu, X.Jiang.

ABSTRACT

No abstract given.