PDBsum entry 4f2c

Metal binding protein

PDB id: 4f2c

Contents

Protein chains

69 a.a.

64 a.a.

Ligands

FES ×2

Waters ×185

PDB id:

4f2c

Name:

Metal binding protein

Title:

The crystal structure of a human mitoneet double mutant in which gly 66 are asp 67 are both replaced with ala residues

Structure:

Cdgsh iron-sulfur domain-containing protein 1. Chain: a, b. Fragment: water-soluble domain, unp residues 33-108. Synonym: mitoneet. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: c10orf70, cisd1, mds029, zcd1. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Resolution:

1.35Å R-factor: 0.154 R-free: 0.181

Authors:

E.L.Baxter,J.A.Zuris,C.Wang,H.L.Axelrod,A.E.Cohen,M.L.Paddock, R.Nechushtai,J.N.Onuchic,P.A.Jennings

Key ref:

E.L.Baxter et al. (2013). Allosteric control in a metalloprotein dramatically alters function. Proc Natl Acad Sci U S A, 110, 948-953. PubMed id: 23271805

Date:

07-May-12 Release date: 26-Dec-12

Protein chain

Q9NZ45  (CISD1_HUMAN) -  CDGSH iron-sulfur domain-containing protein 1 from Homo sapiens

Seq: 108 a.a.

Struc: 69 a.a.*

Protein chain

Q9NZ45  (CISD1_HUMAN) -  CDGSH iron-sulfur domain-containing protein 1 from Homo sapiens

Seq: 108 a.a.

Struc: 64 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Proc Natl Acad Sci U S A 110:948-953 (2013)

PubMed id: 23271805

Allosteric control in a metalloprotein dramatically alters function.

E.L.Baxter, J.A.Zuris, C.Wang, P.L.Vo, H.L.Axelrod, A.E.Cohen, M.L.Paddock, R.Nechushtai, J.N.Onuchic, P.A.Jennings.

ABSTRACT

No abstract given.