Your browser does not support inline frames or is currently configured not to display inline frames. Content can be viewed at actual source page: inc/head.html
PDBsum entry 4erw
Go to PDB code:
Transferase/antibiotic
PDB id
4erw
Loading ...
Contents
Protein chain
293 a.a.
Ligands
STU
EDO
×16
Waters
×114
PDB id:
4erw
Links
PDBe
RCSB
MMDB
JenaLib
Proteopedia
CATH
SCOP
PDBSWS
PDBePISA
ProSAT
Name:
Transferase/antibiotic
Title:
Cdk2 in complex with staurosporine
Structure:
Cyclin-dependent kinase 2. Chain: a. Synonym: cdk2, cell division protein kinase 2, p33 protein kinase. Engineered: yes
Source:
Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.00Å
R-factor:
0.196
R-free:
0.244
Authors:
R.Alam,M.P.Martin,J.-Y.Zhu,E.Schonbrunn
Key ref:
M.P.Martin et al. (2012). A novel approach to the discovery of small-molecule ligands of CDK2.
Chembiochem
,
13
, 2128-2136.
PubMed id:
22893598
Date:
20-Apr-12
Release date:
22-Aug-12
PROCHECK
Headers
References
Protein chain
?
P24941
(CDK2_HUMAN) - Cyclin-dependent kinase 2 from Homo sapiens
Seq:
Struc:
298 a.a.
293 a.a.
*
Key:
PfamA domain
Secondary structure
CATH domain
*
PDB and UniProt seqs differ at 1 residue position (black cross)
Enzyme reactions
Enzyme class:
E.C.2.7.11.22
- cyclin-dependent kinase.
[IntEnz]
[ExPASy]
[KEGG]
[BRENDA]
Reaction:
1.
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H
+
2.
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H
+
L-seryl-[protein]
+
ATP
=
O-phospho-L-seryl-[protein]
+
ADP
+
H(+)
L-threonyl-[protein]
+
ATP
=
O-phospho-L-threonyl-[protein]
+
ADP
+
H(+)
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
reference
Chembiochem
13
:2128-2136 (2012)
PubMed id:
22893598
A novel approach to the discovery of small-molecule ligands of CDK2.
M.P.Martin,
R.Alam,
S.Betzi,
D.J.Ingles,
J.Y.Zhu,
E.Schönbrunn.
ABSTRACT
No abstract given.
Links
