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PDBsum entry 4epr
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PDB id:
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Hydrolase
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Title:
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Discovery of small molecules that bind to k-ras and inhibit sos- mediated activation.
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Structure:
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Gtpase kras. Chain: a. Synonym: k-ras 2, ki-ras, c-k-ras, c-ki-ras, gtpase kras, n- terminally processed. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: kras, kras2, rask2. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.00Å
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R-factor:
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0.203
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R-free:
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0.253
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Authors:
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Q.Sun,J.P.Burke,J.Phan,M.C.Burns,E.T.Olejniczak,A.G.Waterson,T.Lee, O.W.Rossanese,S.W.Fesik
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Key ref:
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Q.Sun
et al.
(2012).
Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation.
Angew Chem Int Ed Engl,
51,
6140-6143.
PubMed id:
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Date:
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17-Apr-12
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Release date:
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23-May-12
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PROCHECK
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Headers
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References
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P01116
(RASK_HUMAN) -
GTPase KRas from Homo sapiens
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Seq:
Struc:
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189 a.a.
166 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 6 residue positions (black
crosses)
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Enzyme class:
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E.C.3.6.5.2
- small monomeric GTPase.
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Reaction:
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GTP + H2O = GDP + phosphate + H+
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GTP
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+
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H2O
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=
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GDP
Bound ligand (Het Group name = )
corresponds exactly
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phosphate
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Angew Chem Int Ed Engl
51:6140-6143
(2012)
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PubMed id:
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Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation.
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Q.Sun,
J.P.Burke,
J.Phan,
M.C.Burns,
E.T.Olejniczak,
A.G.Waterson,
T.Lee,
O.W.Rossanese,
S.W.Fesik.
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ABSTRACT
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Links
