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PDBsum entry 4ej4
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protein ligands links
Signaling protein, hydrolase/antagonist PDB id
4ej4

 

 

 

 

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Contents
Protein chain
442 a.a.
Ligands
EJ4
PDB id:
4ej4
Name: Signaling protein, hydrolase/antagonist
Title: Structure of the delta opioid receptor bound to naltrindole
Structure: Delta-type opioid receptor, lysozyme chimera. Chain: a. Fragment: p32300 residues 36-244, 251-342. Synonym: d-or-1, dor-1, k56, msl-2, endolysin, lysis protein, muramidase. Engineered: yes. Mutation: yes
Source: Mus musculus, enterobacteria phage t4. Organism_taxid: 10090, 10665. Gene: oprd1, e. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Resolution:
3.40Å     R-factor:   0.255     R-free:   0.282
Authors: S.Granier,A.Manglik,A.C.Kruse,T.S.Kobilka,F.S.Thian,W.I.Weis, B.K.Kobilka
Key ref: S.Granier et al. (2012). Structure of the δ-opioid receptor bound to naltrindole. Nature, 485, 400-404. PubMed id: 22596164
Date:
06-Apr-12     Release date:   16-May-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00720  (ENLYS_BPT4) -  Endolysin from Enterobacteria phage T4
Seq:
Struc: 		164 a.a.
442 a.a.*
Protein chain
Pfam   ArchSchema ?
P32300  (OPRD_MOUSE) -  Delta-type opioid receptor from Mus musculus
Seq:
Struc: 		 
Seq:
Struc: 		372 a.a.
442 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 166 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.3.2.1.17  - lysozyme.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Hydrolysis of the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of the prokaryotes cell walls.

 

 
Nature 485:400-404 (2012)
PubMed id: 22596164  
 
 
Structure of the δ-opioid receptor bound to naltrindole.
S.Granier, A.Manglik, A.C.Kruse, T.S.Kobilka, F.S.Thian, W.I.Weis, B.K.Kobilka.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23407534 A.J.Venkatakrishnan, X.Deupi, G.Lebon, C.G.Tate, G.F.Schertler, and M.M.Babu (2013).
Molecular signatures of G-protein-coupled receptors.
  Nature, 494, 185-194.  
23381628 U.Pieper, A.Schlessinger, E.Kloppmann, G.A.Chang, J.J.Chou, M.E.Dumont, B.G.Fox, P.Fromme, W.A.Hendrickson, M.G.Malkowski, D.C.Rees, D.L.Stokes, M.H.Stowell, M.C.Wiener, B.Rost, R.M.Stroud, R.C.Stevens, and A.Sali (2013).
Coordinating the impact of structural genomics on the human α-helical transmembrane proteome.
  Nat Struct Mol Biol, 20, 135-138.  
23222541 C.Zhang, Y.Srinivasan, D.H.Arlow, J.J.Fung, D.Palmer, Y.Zheng, H.F.Green, A.Pandey, R.O.Dror, D.E.Shaw, W.I.Weis, S.R.Coughlin, and B.K.Kobilka (2012).
High-resolution crystal structure of human protease-activated receptor 1.
  Nature, 492, 387-392.
PDB code: 3vw7
23051750 F.Hausch, and F.Holsboer (2012).
Structural biology: Snapshot of an activated peptide receptor.
  Nature, 490, 492-493.  
23051748 J.F.White, N.Noinaj, Y.Shibata, J.Love, B.Kloss, F.Xu, J.Gvozdenovic-Jeremic, P.Shah, J.Shiloach, C.G.Tate, and R.Grisshammer (2012).
Structure of the agonist-bound neurotensin receptor.
  Nature, 490, 508-513.
PDB code: 4grv
23237917 R.C.Stevens, V.Cherezov, V.Katritch, R.Abagyan, P.Kuhn, H.Rosen, and K.Wüthrich (2012).
The GPCR Network: a large-scale collaboration to determine human GPCR structure and function.
  Nat Rev Drug Discov, 12, 25-34.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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