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PDBsum entry 4eiy
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protein ligands metals links
Membrane protein PDB id
4eiy

 

 

 

 

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Contents
Protein chain
390 a.a.
Ligands
ZMA
CLR ×3
OLA ×16
OLC ×6
OLB
PEG ×2
Metals
_NA
Waters ×185
PDB id:
4eiy
Name: Membrane protein
Title: Crystal structure of the chimeric protein of a2aar-bril in complex with zm241385 at 1.8a resolution
Structure: Adenosine receptor a2a/soluble cytochrome b562 chimera. Chain: a. Synonym: cytochrome b-562. Engineered: yes. Mutation: yes
Source: Homo sapiens, escherichia coli. Human. Organism_taxid: 9606, 562. Gene: aa2ar_human, adora2, adora2a, cybc. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Resolution:
1.80Å     R-factor:   0.176     R-free:   0.213
Authors: W.Liu,E.Chun,A.A.Thompson,P.Chubukov,F.Xu,V.Katritch,G.W.Han, L.H.Heitman,A.P.Ijzerman,V.Cherezov,R.C.Stevens,Gpcr Network (Gpcr)
Key ref: W.Liu et al. (2012). Structural basis for allosteric regulation of GPCRs by sodium ions. Science, 337, 232-236. PubMed id: 22798613
Date:
06-Apr-12     Release date:   25-Jul-12    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli
Seq:
Struc: 		128 a.a.
390 a.a.*
Protein chain
Pfam   ArchSchema ?
P29274  (AA2AR_HUMAN) -  Adenosine receptor A2a from Homo sapiens
Seq:
Struc: 		412 a.a.
390 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 110 residue positions (black crosses)

 

 
Science 337:232-236 (2012)
PubMed id: 22798613  
 
 
Structural basis for allosteric regulation of GPCRs by sodium ions.
W.Liu, E.Chun, A.A.Thompson, P.Chubukov, F.Xu, V.Katritch, G.W.Han, C.B.Roth, L.H.Heitman, A.P.IJzerman, V.Cherezov, R.C.Stevens.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23407534 A.J.Venkatakrishnan, X.Deupi, G.Lebon, C.G.Tate, G.F.Schertler, and M.M.Babu (2013).
Molecular signatures of G-protein-coupled receptors.
  Nature, 494, 185-194.  
23407495 Y.Oka, M.Butnaru, L.von Buchholtz, N.J.Ryba, and C.S.Zuker (2013).
High salt recruits aversive taste pathways.
  Nature, 494, 472-475.  
23237917 R.C.Stevens, V.Cherezov, V.Katritch, R.Abagyan, P.Kuhn, H.Rosen, and K.Wüthrich (2012).
The GPCR Network: a large-scale collaboration to determine human GPCR structure and function.
  Nat Rev Drug Discov, 12, 25-34.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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