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PDBsum entry 4ehf
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Hydrolase/hydrolase inhibitor
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PDB id
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4ehf
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Allosteric modulation of caspase-3 through mutagenesis
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Structure:
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Caspase-3. Chain: a. Synonym: casp-3, apopain, cysteine protease cpp32, cpp-32, protein yama, srebp cleavage activity 1, sca-1, caspase-3 subunit p17, caspase-3 subunit p12. Engineered: yes. Mutation: yes. Ace-asp-glu-val-asp-chloromethylketone inhibitor. Chain: b.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: casp3, cpp32. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
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Resolution:
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1.66Å
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R-factor:
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0.163
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R-free:
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0.185
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Authors:
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J.Walters,J.L.Schipper,P.D.Swartz,C.Mattos,A.C.Clark
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Key ref:
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J.Walters
et al.
(2012).
Allosteric modulation of caspase 3 through mutagenesis.
Biosci Rep,
32,
401-411.
PubMed id:
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Date:
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02-Apr-12
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Release date:
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06-Jun-12
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PROCHECK
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Headers
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References
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P42574
(CASP3_HUMAN) -
Caspase-3 from Homo sapiens
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Seq:
Struc:
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277 a.a.
242 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Biosci Rep
32:401-411
(2012)
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PubMed id:
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Allosteric modulation of caspase 3 through mutagenesis.
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J.Walters,
J.L.Schipper,
P.Swartz,
C.Mattos,
A.C.Clark.
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ABSTRACT
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Links
