PDBsum entry 4e4e

Oxidoreductase

PDB id: 4e4e

Contents

Protein chains

206 a.a.

Metals

_MN ×4

Waters ×231

PDB id:

4e4e

Name:

Oxidoreductase

Title:

Crystal structure of the y34f mutant of saccharomyces cerevisiae manganese superoxide dismutase

Structure:

Superoxide dismutase [mn], mitochondrial. Chain: a, b, c, d. Engineered: yes. Mutation: yes

Source:

Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: eg110. Gene: sod2, yhr008c. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.

Resolution:

1.88Å R-factor: 0.192 R-free: 0.231

Authors:

Y.Sheng,D.Cascio,J.S.Valentine

Key ref:

Y.Sheng et al. (2012). Six-coordinate manganese(3+) in catalysis by yeast manganese superoxide dismutase. Proc Natl Acad Sci U S A, 109, 14314-14319. PubMed id: 22908245

Date:

12-Mar-12 Release date: 22-Aug-12

Protein chains

P00447  (SODM_YEAST) -  Superoxide dismutase [Mn], mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 233 a.a.

Struc: 206 a.a.*

* PDB and UniProt seqs differ at 17 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.1.15.1.1 - superoxide dismutase.
• Reaction: 2 superoxide + 2 H⁺ = H2O2 + O2
• Cofactor: Fe cation or Mn(2+) or (Zn(2+) and Cu cation)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Proc Natl Acad Sci U S A 109:14314-14319 (2012)

PubMed id: 22908245

Six-coordinate manganese(3+) in catalysis by yeast manganese superoxide dismutase.

Y.Sheng, E.Butler Gralla, M.Schumacher, D.Cascio, D.E.Cabelli, J.S.Valentine.

ABSTRACT

No abstract given.