PDBsum entry 4dsa

Hydrolase/hydrolase inhibitor

PDB id: 4dsa

Contents

Protein chain

724 a.a.

Ligands

D1C

PDB id:

4dsa

Name:

Hydrolase/hydrolase inhibitor

Title:

Crystal structure of dpp-iv with compound c1

Structure:

Dipeptidyl peptidase 4. Chain: a, b. Fragment: extracellular domain (residues 39-766). Synonym: dipeptidyl peptidase iv, dpp iv. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f cell.

Resolution:

3.25Å R-factor: 0.202 R-free: 0.266

Authors:

B.Xiong,L.R.Zhu,D.Q.Chen,Y.L.Zhao,F.Jiang,J.K.Shen

Key ref:

B.Xiong et al. Crystal structure of dpp-Iv with compound c1. To be published, .

Date:

18-Feb-12 Release date: 27-Feb-13

Protein chains

P27487  (DPP4_HUMAN) -  Dipeptidyl peptidase 4 from Homo sapiens

Seq: 766 a.a.

Struc: 724 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.14.5 - dipeptidyl-peptidase Iv.
• Reaction: Release of an N-terminal dipeptide, Xaa-Xbb-|-Xcc, from a polypeptide, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline.