PDBsum entry 4dos

Transcription

PDB id: 4dos

Contents

Protein chains

242 a.a.

11 a.a.

Ligands

ASN-ALA-LEU-LEU-ARG-TYR-LEU-LEU-ASP-LYS

1PE ×3

PLC

Waters ×138

PDB id:

4dos

Name:

Transcription

Title:

Human nuclear receptor liver receptor homologue-1, lrh-1, bound to dlpc and a fragment of tif-2

Structure:

Nuclear receptor subfamily 5 group a member 2. Chain: a. Fragment: ligand binding domain, unp residues 299-538. Synonym: alpha-1-fetoprotein transcription factor, b1-binding factor, hb1f, cyp7a promoter-binding factor, hepatocytic transcription factor, liver receptor homolog 1, lrh-1. Engineered: yes. Nuclear receptor coactivator 2. Chain: b, c.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: b1f, cpf, ftf, lrh-1, nr5a2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606

Resolution:

2.00Å R-factor: 0.191 R-free: 0.238

Authors:

P.M.Musille,E.A.Ortlund

Key ref:

P.M.Musille et al. (2012). Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation. Nat Struct Biol, 19, 532-537. PubMed id: 22504882

Date:

10-Feb-12 Release date: 18-Apr-12

Protein chain

O00482  (NR5A2_HUMAN) -  Nuclear receptor subfamily 5 group A member 2 from Homo sapiens

Seq: 541 a.a.

Struc: 242 a.a.*

Protein chain

Q15596  (NCOA2_HUMAN) -  Nuclear receptor coactivator 2 from Homo sapiens

Seq: 1464 a.a.

Struc: 11 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, C: E.C.?

Nat Struct Biol 19:532-537 (2012)

PubMed id: 22504882

Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation.

P.M.Musille, M.C.Pathak, J.L.Lauer, W.H.Hudson, P.R.Griffin, E.A.Ortlund.

ABSTRACT

No abstract given.