PDBsum entry 4df1

Lyase/lyase inhibitor

PDB id: 4df1

Contents

Protein chains

199 a.a.

Ligands

BMP ×2

Metals

_NI ×2

Waters ×323

PDB id:

4df1

Name:

Lyase/lyase inhibitor

Title:

Crystal structure of orotidine 5'-monophosphate decarboxylase from thermoproteus neutrophilus complexed with inhibitor bmp

Structure:

Orotidine 5'-phosphate decarboxylase. Chain: a, b. Engineered: yes

Source:

Thermoproteus neutrophilus. Organism_taxid: 444157. Strain: dsm 2338 / jcm 9278 / v24sta. Gene: tneu_0023. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.90Å R-factor: 0.151 R-free: 0.179

Authors:

A.A.Fedorov,E.V.Fedorov,B.Desai,J.A.Gerlt,S.C.Almo

Key ref:

A.A.Fedorov et al. Crystal structure of orotidine 5'-Monophosphate decarboxylase from thermoproteus neutrophilus complex inhibitor bmp. To be published, .

Date:

22-Jan-12 Release date: 23-Jan-13

Protein chains

B1Y9Q9  (B1Y9Q9_PYRNV) -  Orotidine 5'-phosphate decarboxylase from Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)

Seq: 202 a.a.

Struc: 199 a.a.

Enzyme reactions

• Enzyme class: E.C.4.1.1.23 - orotidine-5'-phosphate decarboxylase.
• Pathway: Pyrimidine Biosynthesis
• Reaction: orotidine 5'-phosphate + H⁺ = UMP + CO2

Molecule diagrams generated from .mol files obtained from the KEGG ftp site