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PDBsum entry 4dds
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Hydrolase/hydrolase inhibitor
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PDB id
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4dds
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Ctx-m-9 class a beta-lactamase complexed with compound 11
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Structure:
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Beta-lactamase. Chain: a, b. Fragment: unp residues 30-291. Synonym: beta-lactamase ctx-m, beta-lactamase ctx-m-9a, betalactamase ctx-m-9, ctx-m-9 beta-lactamase, ctx-m-9 extended-spectrum beta- lactamase. Engineered: yes
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Source:
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Escherichia coli. Organism_taxid: 562. Gene: blactx-m-9, blactx-m-9a, blactx-m-9b, ctx-m. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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1.36Å
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R-factor:
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0.158
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R-free:
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0.199
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Authors:
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D.A.Nichols,Y.Chen
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Key ref:
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D.A.Nichols
et al.
(2012).
Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase.
J Med Chem,
55,
2163-2172.
PubMed id:
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Date:
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19-Jan-12
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Release date:
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28-Mar-12
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PROCHECK
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Headers
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References
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Q9L5C8
(Q9L5C8_ECOLX) -
Beta-lactamase from Escherichia coli
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Seq:
Struc:
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291 a.a.
260 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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J Med Chem
55:2163-2172
(2012)
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PubMed id:
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Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase.
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D.A.Nichols,
P.Jaishankar,
W.Larson,
E.Smith,
G.Liu,
R.Beyrouthy,
R.Bonnet,
A.R.Renslo,
Y.Chen.
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ABSTRACT
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Links
