PDBsum entry 4dch

Transferase

PDB id: 4dch

Contents

Protein chain

434 a.a.

Ligands

GLC

4DC

Metals

IOD ×2

Waters ×311

PDB id:

4dch

Name:

Transferase

Title:

Insights into glucokinase activation mechanism: observation of multiple distinct protein conformations

Structure:

Glucokinase. Chain: a. Synonym: hexokinase type iv, hk iv, hexokinase-4, hk4, hexokinase-d. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gck. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.79Å R-factor: 0.200 R-free: 0.231

Authors:

S.E.Greasley,M.Hickey,J.Feng,E.Garcia

Key ref:

S.Liu et al. (2012). Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations. J Biol Chem, 287, 13598-13610. PubMed id: 22298776

Date:

17-Jan-12 Release date: 08-Feb-12

Protein chain

P35557  (HXK4_HUMAN) -  Hexokinase-4 from Homo sapiens

Seq: 465 a.a.

Struc: 434 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.1.1 - hexokinase.
• Reaction: a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H⁺

D-hexose + ATP (Bound ligand (Het Group name = GLC) corresponds exactly) = D-hexose 6-phosphate + ADP + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

J Biol Chem 287:13598-13610 (2012)

PubMed id: 22298776

Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations.

S.Liu, M.J.Ammirati, X.Song, J.D.Knafels, J.Zhang, S.E.Greasley, J.A.Pfefferkorn, X.Qiu.

ABSTRACT

No abstract given.