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PDBsum entry 4cpy
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PDB id:
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Hydrolase
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Title:
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Structure of the neuraminidase from the b/lyon/chu/15.216/2011 virus in complex with oseltamivir
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Structure:
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Neuraminidase. Chain: a, b. Ec: 3.2.1.18
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Source:
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Influenza b virus. Organism_taxid: 11520. Strain: b/lyon/chu/15.216/2011
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Resolution:
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1.80Å
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R-factor:
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0.172
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R-free:
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0.179
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Authors:
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S.G.Vachieri,P.J.Collins,V.Escuret,J.S.Casalegno,N.Cattle,O.Ferraris, M.Sabatier,E.Frobert,V.Caro,J.J.Skehel,S.J.Gamblin,F.Valla, M.Valette,M.Ottmann,J.W.Mccauley,R.S.Daniels,B.Lina
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Key ref:
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V.Escuret
et al.
(2014).
A novel I221L substitution in neuraminidase confers high-level resistance to oseltamivir in influenza B viruses.
J Infect Dis,
210,
1260-1269.
PubMed id:
DOI:
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Date:
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09-Feb-14
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Release date:
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14-May-14
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PROCHECK
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Headers
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References
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U5XBU0
(U5XBU0_9INFB) -
Neuraminidase from Influenza B virus
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Seq:
Struc:
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466 a.a.
390 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.3.2.1.18
- exo-alpha-sialidase.
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Reaction:
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Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
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DOI no:
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J Infect Dis
210:1260-1269
(2014)
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PubMed id:
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A novel I221L substitution in neuraminidase confers high-level resistance to oseltamivir in influenza B viruses.
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V.Escuret,
P.J.Collins,
J.S.Casalegno,
S.G.Vachieri,
N.Cattle,
O.Ferraris,
M.Sabatier,
E.Frobert,
V.Caro,
J.J.Skehel,
S.Gamblin,
F.Valla,
M.Valette,
M.Ottmann,
J.W.McCauley,
R.S.Daniels,
B.Lina.
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ABSTRACT
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