PDBsum entry 4b5o

Transferase

PDB id: 4b5o

Contents

Protein chain

192 a.a.

Ligands

ACO

Metals

_NA

Waters ×401

PDB id:

4b5o

Name:

Transferase

Title:

Crystal structure of human alpha tubulin acetyltransferase catalytic domain

Structure:

Alpha-tubulin n-acetyltransferase. Chain: a. Fragment: catalytic domain, residues 1-196. Synonym: alpha-tubulin acetyltransferase, alpha-tat, tat, acetyltransferase mec-17 homolog. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.05Å R-factor: 0.132 R-free: 0.157

Authors:

M.Taschner,M.Vetter,E.Lorentzen

Key ref:

M.Taschner et al. (2012). Atomic resolution structure of human α-tubulin acetyltransferase bound to acetyl-CoA. Proc Natl Acad Sci U S A, 109, 19649-19654. PubMed id: 23071318

Date:

07-Aug-12 Release date: 24-Oct-12

Protein chain

Q5SQI0  (ATAT_HUMAN) -  Alpha-tubulin N-acetyltransferase 1 from Homo sapiens

Seq: 421 a.a.

Struc: 192 a.a.

Enzyme reactions

• Enzyme class: E.C.2.3.1.108 - alpha-tubulin N-acetyltransferase.
• Reaction: L-lysyl-[alpha-tubulin] + acetyl-CoA = N₆-acetyl-L-lysyl-[alpha- tubulin] + CoA + H⁺

L-lysyl-[alpha-tubulin] (Bound ligand (Het Group name = ACO) corresponds exactly) + acetyl-CoA = N(6)-acetyl-L-lysyl-[alpha- tubulin] + CoA + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Proc Natl Acad Sci U S A 109:19649-19654 (2012)

PubMed id: 23071318

Atomic resolution structure of human α-tubulin acetyltransferase bound to acetyl-CoA.

M.Taschner, M.Vetter, E.Lorentzen.

ABSTRACT

No abstract given.