PDBsum entry 4awm

Hydrolase/inhibitor

PDB id: 4awm

Contents

Protein chain

178 a.a.

Ligands

KDH ×2

Metals

_MN ×2

Waters ×30

PDB id:

4awm

Name:

Hydrolase/inhibitor

Title:

Influenza strain ph1n1 2009 polymerase subunit pa endonuclease in complex with (-)-epigallocatechin gallate from green tea

Structure:

Polymerase pa. Chain: a. Fragment: endonuclease, residues 1-198. Engineered: yes

Source:

Influenza a virus. Organism_taxid: 641501. Strain: (a/california/04/2009(h1n1). Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: synthetic gene

Resolution:

2.60Å R-factor: 0.226 R-free: 0.278

Authors:

E.Kowalinski,C.Zubieta,A.Wolkerstorfer,O.H.Szolar,R.W.Ruigrok, S.Cusack

Key ref:

E.Kowalinski et al. (2012). Structural analysis of specific metal chelating inhibitor binding to the endonuclease domain of influenza pH1N1 (2009) polymerase. Plos Pathog, 8, e1002831. PubMed id: 22876177

Date:

04-Jun-12 Release date: 22-Aug-12

Protein chain

C3W5S0  (C3W5S0_I09A0) -  Polymerase acidic protein from Influenza A virus (strain swl A/California/04/2009 H1N1)

Seq: 716 a.a.

Struc: 178 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.1.-.-

Plos Pathog 8:e1002831 (2012)

PubMed id: 22876177

Structural analysis of specific metal chelating inhibitor binding to the endonuclease domain of influenza pH1N1 (2009) polymerase.

E.Kowalinski, C.Zubieta, A.Wolkerstorfer, O.H.Szolar, R.W.Ruigrok, S.Cusack.

ABSTRACT

No abstract given.