PDBsum entry 4zl1

Oxidoreductase/oxidoreductase inhibitor

PDB id: 4zl1

Contents

Protein chain

365 a.a.

Ligands

ORO

FMN

18X

SO4 ×4

Waters ×222

PDB id:

4zl1

Name:

Oxidoreductase/oxidoreductase inhibitor

Title:

Crystal structure of human dihydroorotate dehydrogenase (dhodh) with 18x at 1.86 a resolution

Structure:

Dihydroorotate dehydrogenase (quinone), mitochondrial. Chain: a. Synonym: dhodehase,dihydroorotate oxidase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dhodh. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768.

Resolution:

1.86Å R-factor: 0.161 R-free: 0.179

Authors:

J.Huang,D.Wu,P.Ouyang,W.Lu,J.Pu

Key ref:

J.Huang et al. Crystal structure of human dihydroorotate dehydrogena (dhodh) with 18xyw at 1.86 a resolution. To be published, .

Date:

01-May-15 Release date: 04-May-16

Protein chain

Q02127  (PYRD_HUMAN) -  Dihydroorotate dehydrogenase (quinone), mitochondrial from Homo sapiens

Seq: 395 a.a.

Struc: 365 a.a.

Enzyme reactions

• Enzyme class: E.C.1.3.5.2 - dihydroorotate dehydrogenase (quinone).
• Reaction: (S)-dihydroorotate + a quinone = orotate + a quinol

(S)-dihydroorotate (Bound ligand (Het Group name = ORO) corresponds exactly) + quinone = orotate + quinol

• Cofactor: FMN

FMN (Bound ligand (Het Group name = FMN) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site