PDBsum entry 4y3r

Hydrolase

PDB id: 4y3r

Contents

Protein chain

330 a.a.

Ligands

GOL ×2

F06

ACT

DMS

Waters ×296

PDB id:

4y3r

Name:

Hydrolase

Title:

Endothiapepsin in complex with fragment 306

Structure:

Endothiapepsin. Chain: a. Synonym: aspartate protease. Ec: 3.4.23.22

Source:

Cryphonectria parasitica. Chesnut blight fungus. Organism_taxid: 5116

Resolution:

1.13Å R-factor: 0.125 R-free: 0.141

Authors:

X.Wang,A.Heine,G.Klebe

Key ref:

X.Wang et al. Crystallographic fragment screening of an entire libr. To be published, .

Date:

10-Feb-15 Release date: 17-Feb-16

Protein chain

P11838  (CARP_CRYPA) -  Endothiapepsin from Cryphonectria parasitica

Seq: 419 a.a.

Struc: 330 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.23.22 - endothiapepsin.
• Reaction: Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but does not cleave 14-Ala-|-Leu-15 in the B chain of insulin or Z-Glu-Tyr. Clots milk.