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PDBsum entry 4xmp
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protein ligands Protein-protein interface(s) links
Immune system PDB id
4xmp

 

 

 

 

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Contents
Protein chains
337 a.a.
232 a.a.
211 a.a.
Ligands
NAG ×11
BU3 ×2
Waters ×628
PDB id:
4xmp
Name: Immune system
Title: Crystal structure of broadly and potently neutralizing antibody vrc08 in complex with HIV-1 clade a strain q842.D12 gp120
Structure: Envelope glycoprotein gp160,envelope glycoprotein gp160, envelope glycoprotein gp160. Chain: g. Fragment: unp residues 43-122, 195-297, 319-481. Engineered: yes. Heavy chain of antibody vrc08. Chain: h. Engineered: yes. Light chain of antibody vrc08.
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: q842.D12. Gene: env. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293 gnti-. Homo sapiens. Human.
Resolution:
1.78Å     R-factor:   0.166     R-free:   0.201
Authors: T.Zhou,S.Srivatsan,P.D.Kwong
Key ref: X.Wu et al. (2015). Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection. Cell, 161, 470-485. PubMed id: 25865483 DOI: 10.1016/j.cell.2015.03.004
Date:
15-Jan-15     Release date:   29-Apr-15    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q8JDI3  (Q8JDI3_9HIV1) -  Envelope glycoprotein gp160 from Human immunodeficiency virus 1
Seq:
Struc: 		 
Seq:
Struc: 		852 a.a.
337 a.a.*
Protein chain
Pfam   ArchSchema ?
P01857  (IGHG1_HUMAN) -  Immunoglobulin heavy constant gamma 1 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		399 a.a.
232 a.a.
Protein chain
Pfam   ArchSchema ?
P01834  (IGKC_HUMAN) -  Immunoglobulin kappa constant from Homo sapiens
Seq:
Struc: 		107 a.a.
211 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 

 
DOI no: 10.1016/j.cell.2015.03.004 Cell 161:470-485 (2015)
PubMed id: 25865483  
 
 
Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection.
X.Wu, Z.Zhang, C.A.Schramm, M.G.Joyce, Y.D.Kwon, T.Zhou, Z.Sheng, B.Zhang, S.O'Dell, K.McKee, I.S.Georgiev, G.Y.Chuang, N.S.Longo, R.M.Lynch, K.O.Saunders, C.Soto, S.Srivatsan, Y.Yang, R.T.Bailer, M.K.Louder, J.C.Mullikin, M.Connors, P.D.Kwong, J.R.Mascola, L.Shapiro, B.Benjamin, R.Blakesley, G.Bouffard, S.Brooks, H.Coleman, M.Dekhtyar, M.Gregory, X.Guan, J.Gupta, J.Han, A.Hargrove, S.L.Ho, R.Legaspi, Q.Maduro, C.Masiello, B.Maskeri, J.McDowell, C.Montemayor, M.Park, N.Riebow, K.Schandler, B.Schmidt, C.Sison, M.Stantripop, J.Thomas, P.Thomas, M.Vemulapalli, A.Young.
 
  ABSTRACT  
 
No abstract given.

 

 

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