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PDBsum entry 4wht
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Viral protein PDB id
4wht

 

 

 

 

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Contents
Protein chains
(+ 6 more) 207 a.a.
(+ 6 more) 215 a.a.
12 a.a.
11 a.a.
11 a.a.
Ligands
LEU-ILE-ASN-THR-
ASN-GLY-SER-TRP-
HIS-VAL ×2
Waters ×850
PDB id:
4wht
Name: Viral protein
Title: Structure of the hepatitis c virus envelope glycoprotein e2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, p1 crystal form
Structure: Heavy chain of the fab fragment derived from neutralizing antibody 3/11. Chain: a, c, e, g, i, k, m, o, q, s, u, x. Engineered: yes. Light chain of the fab fragment derived from neutralizing antibody 3/11. Chain: j, b, d, f, h, l, n, p, r, t, v, y. Engineered: yes. Epitope peptide.
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Expression_system_cell_line: schneider 2. Hepatitis c virus. Organism_taxid: 11103. Expressed in: synthetic construct.
Resolution:
2.22Å     R-factor:   0.211     R-free:   0.243
Authors: T.Krey,F.A.Rey
Key ref: A.Meola et al. (2015). Structural flexibility of a conserved antigenic region in hepatitis C virus glycoprotein E2 recognized by broadly neutralizing antibodies. J Virol, 89, 2170-2181. PubMed id: 25473061 DOI: 10.1128/JVI.02190-14
Date:
23-Sep-14     Release date:   17-Dec-14    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
No UniProt id for this chain
Struc: 207 a.a.
Protein chains
No UniProt id for this chain
Struc: 215 a.a.
Protein chains
Pfam   ArchSchema ?
Q9WJJ4  (Q9WJJ4_9HEPC) -  Genome polyprotein (Fragment) from Hepacivirus hominis
Seq:
Struc: 		75 a.a.
12 a.a.
Protein chains
Pfam   ArchSchema ?
Q9WJJ4  (Q9WJJ4_9HEPC) -  Genome polyprotein (Fragment) from Hepacivirus hominis
Seq:
Struc: 		75 a.a.
11 a.a.
Protein chain
Pfam   ArchSchema ?
Q9WJJ4  (Q9WJJ4_9HEPC) -  Genome polyprotein (Fragment) from Hepacivirus hominis
Seq:
Struc: 		75 a.a.
11 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 

 
DOI no: 10.1128/JVI.02190-14 J Virol 89:2170-2181 (2015)
PubMed id: 25473061  
 
 
Structural flexibility of a conserved antigenic region in hepatitis C virus glycoprotein E2 recognized by broadly neutralizing antibodies.
A.Meola, A.W.Tarr, P.England, L.W.Meredith, C.P.McClure, S.K.Foung, J.A.McKeating, J.K.Ball, F.A.Rey, T.Krey.
 
  ABSTRACT  
 
No abstract given.

 

 

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