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PDBsum entry 4ui6
Go to PDB code: 
protein ligands metals Protein-protein interface(s) links
Transferase PDB id
4ui6

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
161 a.a.
47 a.a.
Ligands
ECZ ×2
SO4 ×4
GOL ×2
Metals
_ZN ×2
Waters ×427
PDB id:
4ui6
Name: Transferase
Title: Crystal structure of human tankyrase 2 in complex with ta-47
Structure: Tankyrase-2. Chain: a, b. Fragment: c-terminal fragment, residues 946-1113. Synonym: tank2, adp-ribosyltransferase diphtheria toxin-like 6, artd6, poly [adp-ribose] polymerase 5b, tnks-2, trf1-interacting ankyrin-related adp-ribose polymerase 2, tankyrase ii, tankyrase-like protein, tankyrase-related protein. Engineered: yes. Tankyrase-2.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Resolution:
1.80Å     R-factor:   0.155     R-free:   0.186
Authors: T.Haikarainen,L.Lehtio
Key ref: A.Nathubhai et al. (2016). Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. Eur J Med Chem, 118, 316-327. PubMed id: 27163581 DOI: 10.1016/j.ejmech.2016.04.041
Date:
27-Mar-15     Release date:   13-Apr-16    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q9H2K2  (TNKS2_HUMAN) -  Poly [ADP-ribose] polymerase tankyrase-2 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1166 a.a.
161 a.a.
Protein chains
Pfam   ArchSchema ?
Q9H2K2  (TNKS2_HUMAN) -  Poly [ADP-ribose] polymerase tankyrase-2 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1166 a.a.
47 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class 2: Chains A, B, C, D: E.C.2.4.2.-  - ?????
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
   Enzyme class 3: Chains A, B, C, D: E.C.2.4.2.30  - NAD(+) ADP-ribosyltransferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
      Reaction: NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H+
NAD(+)
 + (ADP-D-ribosyl)n-acceptor
 = nicotinamide
 + (ADP-D- ribosyl)n+1-acceptor
 + H(+)
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Added reference    
 
 
DOI no: 10.1016/j.ejmech.2016.04.041 Eur J Med Chem 118:316-327 (2016)
PubMed id: 27163581  
 
 
Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases.
A.Nathubhai, T.Haikarainen, P.C.Hayward, S.Muñoz-Descalzo, A.S.Thompson, M.D.Lloyd, L.Lehtiö, M.D.Threadgill.
 
  ABSTRACT  
 
No abstract given.

 

 

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