PDBsum entry 4qn6

Hydrolase

PDB id: 4qn6

Contents

Protein chains

389 a.a.

Ligands

NAG-NAG-BMA ×2

NAG-NAG-BMA-MAN-MAN-MAN ×2

LNV ×2

Metals

_CA ×2

Waters ×846

PDB id:

4qn6

Name:

Hydrolase

Title:

Crystal structure of neuraminidase n6 complexed with laninamivir

Structure:

Neuraminidase. Chain: a, b. Fragment: unp residues 80-470. Engineered: yes

Source:

Influenza a virus (a/chicken/nanchang/7- 010/2000(h3n6)). Organism_taxid: 215864. Gene: na. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Resolution:

1.95Å R-factor: 0.146 R-free: 0.161

Authors:

X.Sun,Q.Li,Y.Wu,Y.Liu,J.Qi,C.J.Vavricka,G.F.Gao

Key ref:

X.Sun et al. (2014). Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle. J Virol, 88, 9197-9207. PubMed id: 24899180 DOI: 10.1128/JVI.00805-14

Date:

17-Jun-14 Release date: 30-Jul-14

Protein chains

Q2FCL6  (Q2FCL6_9INFA) -  Neuraminidase from Influenza A virus

Seq: 470 a.a.

Struc: 389 a.a.

Enzyme reactions

• Enzyme class: E.C.3.2.1.18 - exo-alpha-sialidase.
• Reaction: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

DOI no: 10.1128/JVI.00805-14

J Virol 88:9197-9207 (2014)

PubMed id: 24899180

Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle.

X.Sun, Q.Li, Y.Wu, M.Wang, Y.Liu, J.Qi, C.J.Vavricka, G.F.Gao.

ABSTRACT

No abstract given.