PDBsum entry 4py8

Viral protein/immune system

PDB id: 4py8

Contents

Protein chains

328 a.a.

171 a.a.

219 a.a.

212 a.a.

Ligands

NAG-NAG

NAG ×2

MLI ×2

PDB id:

4py8

Name:

Viral protein/immune system

Title:

Crystal structure of fab 3.1 in complex with the 1918 influenza virus hemagglutinin

Structure:

Hemagglutinin ha1 chain. Chain: a. Fragment: receptor binding subunit (unp residues 18-344). Engineered: yes. Hemagglutinin ha2 chain. Chain: b. Fragment: membrane fusion subunit (unp residues 345-520). Engineered: yes. Antibody 3.1 heavy chain.

Source:

Influenza a virus. Organism_taxid: 59375. Strain: a/south carolina/1/1918(h1n1). Gene: ha, hemagglutinin. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five. Homo sapiens. Human.

Resolution:

2.91Å R-factor: 0.196 R-free: 0.242

Authors:

C.Dreyfus

Key ref:

A.Wyrzucki et al. (2014). Alternative recognition of the conserved stem epitope in influenza A virus hemagglutinin by a VH3-30-encoded heterosubtypic antibody. J Virol, 88, 7083-7092. PubMed id: 24719426 DOI: 10.1128/JVI.00178-14

Date:

26-Mar-14 Release date: 21-May-14

Protein chain

Q9WFX3  (HEMA_I18A0) -  Hemagglutinin from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1)

Seq: 566 a.a.

Struc: 328 a.a.*

Protein chain

Q9WFX3  (HEMA_I18A0) -  Hemagglutinin from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1)

Seq: 566 a.a.

Struc: 171 a.a.

Protein chain

No UniProt id for this chain

Struc: 219 a.a.

Protein chain

No UniProt id for this chain

Struc: 212 a.a.

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

DOI no: 10.1128/JVI.00178-14

J Virol 88:7083-7092 (2014)

PubMed id: 24719426

Alternative recognition of the conserved stem epitope in influenza A virus hemagglutinin by a VH3-30-encoded heterosubtypic antibody.

A.Wyrzucki, C.Dreyfus, I.Kohler, M.Steck, I.A.Wilson, L.Hangartner.

ABSTRACT

No abstract given.