PDBsum entry 4p4n

Oxidoreductase

PDB id

4p4n

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Contents

			Protein chains

					264 a.a.

			Ligands

					SO4 ×5

			Waters ×346

PDB id:

4p4n

Links

Name:

Oxidoreductase

Title:

Crystal structure of mycobacterium tuberculosis shikimate dehydrogenase

Structure:

Shikimate 5-dehydrogenase aroe (5-dehydroshikimate reductase). Chain: a, b, c. Synonym: shikimate 5-dehydrogenase. Engineered: yes

Source:

Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: aroe, mt2629, rv2552c. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.95Å

R-factor:

0.188

R-free:

0.229

Authors:

M.Lalgondar,J.C.Sacchettini,Tb Structural Genomics Consortium (Tbsgc)

Date:

12-Mar-14

Release date:

18-Mar-15

PROCHECK

	Headers

	References

Protein chains

I6Y120 (I6Y120_MYCTU) - Probable shikimate 5-dehydrogenase AroE (5-dehydroshikimate reductase) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: Struc:					269 a.a. 264 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.1.1.1.25 - shikimate dehydrogenase (NADP(+)).

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Pathway:

Shikimate and Chorismate Biosynthesis

Reaction:

shikimate + NADP⁺ = 3-dehydroshikimate + NADPH + H⁺

shikimate	+	NADP(+)	=	3-dehydroshikimate	+	NADPH	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site