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PDBsum entry 4olc
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protein ligands Protein-protein interface(s) links
Transferase PDB id
4olc

 

 

 

 

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Contents
Protein chains
308 a.a.
Ligands
CIT ×4
DCD ×3
Waters ×265
PDB id:
4olc
Name: Transferase
Title: Carbamate kinase from giardia lamblia thiocarbamoylated by disulfiram on cys242
Structure: Carbamate kinase. Chain: a, b, c, d. Engineered: yes
Source: Giardia lamblia. Organism_taxid: 184922. Strain: atcc 50803 / wb clone c6. Gene: gl50803_16453. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
2.60Å     R-factor:   0.206     R-free:   0.274
Authors: K.Lim,O.Herzberg
Key ref: A.Galkin et al. (2014). Structural basis for inactivation of Giardia lamblia carbamate kinase by disulfiram. J Biol Chem, 289, 10502-10509. PubMed id: 24558036 DOI: 10.1074/jbc.M114.553123
Date:
23-Jan-14     Release date:   26-Feb-14    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
A8BB85  (A8BB85_GIAIC) -  Carbamate kinase from Giardia intestinalis (strain ATCC 50803 / WB clone C6)
Seq:
Struc: 		316 a.a.
308 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.2.2  - carbamate kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway: 		AMP Catabolism
      Reaction: hydrogencarbonate + NH4+ + ATP = carbamoyl phosphate + ADP + H2O + H+
hydrogencarbonate
 + NH4(+)
 + ATP
 = carbamoyl phosphate
 + ADP
 + H2O
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    reference    
 
 
DOI no: 10.1074/jbc.M114.553123 J Biol Chem 289:10502-10509 (2014)
PubMed id: 24558036  
 
 
Structural basis for inactivation of Giardia lamblia carbamate kinase by disulfiram.
A.Galkin, L.Kulakova, K.Lim, C.Z.Chen, W.Zheng, I.V.Turko, O.Herzberg.
 
  ABSTRACT  
 
No abstract given.

 

 

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