 |
PDBsum entry 4l1m
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Ligase
|
|
|
Title:
|
|
Structure of the first rcc1-like domain of herc2
|
|
Structure:
|
|
E3 ubiquitin-protein ligase herc2. Chain: a, b, c. Synonym: hect domain and rcc1-like domain-containing protein 2. Engineered: yes
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Gene: herc2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
Resolution:
|
|
|
2.60Å
|
R-factor:
|
0.201
|
R-free:
|
0.238
|
|
|
Authors:
|
|
W.Tempel,M.B.Khan,A.Dong,J.Hu,Y.Li,C.Bountra,C.H.Arrowsmith, A.M.Edwards,Y.Tong,Structural Genomics Consortium (Sgc)
|
|
Key ref:
|
|
W.Tempel
et al.
Structure of the first rcc1-Like domain of herc2.
To be published,
.
|
|
|
Date:
|
|
|
03-Jun-13
|
Release date:
|
03-Jul-13
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
O95714
(HERC2_HUMAN) -
E3 ubiquitin-protein ligase HERC2 from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
4834 a.a.
358 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.2.3.2.26
- HECT-type E3 ubiquitin transferase.
|
|
|
|
|
|
|
Reaction:
|
|
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6- ubiquitinyl-[acceptor protein]-L-lysine
|
|
|
|
|
|
|
|
Links
