PDBsum entry 4hje

Transcription/DNA

PDB id: 4hje

Contents

Protein chains

200 a.a.

DNA/RNA

Metals

_ZN ×4

Waters ×832

PDB id:

4hje

Name:

Transcription/DNA

Title:

Crystal structure of p53 core domain in complex with DNA

Structure:

Cellular tumor antigen p53. Chain: a, b, c, d. Fragment: unp residues 92-291. Synonym: antigen ny-co-13, phosphoprotein p53, tumor suppressor p53. Engineered: yes. DNA (5'- d( Tp Cp Ap Cp Ap Ap Gp Tp Tp Ap Gp Ap Gp Ap Cp Ap Ap Gp Cp Cp T)- 3'). Chain: e.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: tp53, p53. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in humans. Other_details: this sequence occurs naturally in humans

Resolution:

1.91Å R-factor: 0.189 R-free: 0.228

Authors:

Y.Chen,L.Chen

Key ref:

Y.Chen et al. (2013). Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion. Nucleic Acids Res, 41, 8368-8376. PubMed id: 23836939 DOI: 10.1093/nar/gkt584

Date:

12-Oct-12 Release date: 17-Jul-13

Protein chains

P04637  (P53_HUMAN) -  Cellular tumor antigen p53 from Homo sapiens

Seq: 393 a.a.

Struc: 200 a.a.

DNA/RNA chains

T-C-A-C-A-A-G-T-T-A-G-A-G-A-C-A-A-G-C-C-T 21 bases

A-G-G-C-T-T-G-T-C-T-C-T-A-A-C-T-T-G-T-G-A 21 bases

Enzyme reactions

• Enzyme class: E.C.?

DOI no: 10.1093/nar/gkt584

Nucleic Acids Res 41:8368-8376 (2013)

PubMed id: 23836939

Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion.

Y.Chen, X.Zhang, A.C.Dantas Machado, Y.Ding, Z.Chen, P.Z.Qin, R.Rohs, L.Chen.

ABSTRACT

No abstract given.