PDBsum entry 4hgs

Transferase/transferase inhibitor

PDB id: 4hgs

Contents

Protein chain

302 a.a.

Ligands

15G

Waters ×148

PDB id:

4hgs

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of ck1gs with compound 13

Structure:

Casein kinase i isoform gamma-3. Chain: a. Fragment: unp residues 34-362. Synonym: cki-gamma 3. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: csnk1g3. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.40Å R-factor: 0.250 R-free: 0.280

Authors:

X.Huang

Key ref:

X.Huang et al. Crystal structure of ck1gs with compound 13. Acs med chem lett, .

Date:

08-Oct-12 Release date: 21-Nov-12

Protein chain

Q9Y6M4  (KC1G3_HUMAN) -  Casein kinase I isoform gamma-3 from Homo sapiens

Seq: 447 a.a.

Struc: 302 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site