PDBsum entry 4h0r

Transferase

PDB id: 4h0r

Contents

Protein chains

256 a.a.

Waters ×196

PDB id:

4h0r

Name:

Transferase

Title:

Crystal structure of thymidylate synthase from corynebacterium glutamicum

Structure:

Thymidylate synthase. Chain: a, b. Synonym: ts, tsase. Engineered: yes

Source:

Corynebacterium glutamicum. Organism_taxid: 196627. Strain: atcc 13032 / dsm 20300 / jcm 1318 / lmg 3730 / ncimb 10025. Gene: cg0966, cgl0844, thya. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.30Å R-factor: 0.186 R-free: 0.231

Authors:

C.M.Chang,W.C.Wang

Key ref:

C.M.Chang and w.c.wang Crystal structure of thymidylate synthase from corynebacterium glutamicum. To be published, .

Date:

10-Sep-12 Release date: 11-Sep-13

Protein chains

Q8NS38  (TYSY_CORGL) -  Thymidylate synthase from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)

Seq: 266 a.a.

Struc: 256 a.a.

Enzyme reactions

• Enzyme class: E.C.2.1.1.45 - thymidylate synthase.
• Pathway: Folate Coenzymes
• Reaction: dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP

Molecule diagrams generated from .mol files obtained from the KEGG ftp site