PDBsum entry 4g9f

Immune system

PDB id: 4g9f

Contents

Protein chains

276 a.a.

100 a.a.

204 a.a.

250 a.a.

Ligands

LYS-ARG-TRP-ILE-ILE-MET-GLY-LEU-ASN-LYS

SO4 ×3

Waters ×486

PDB id:

4g9f

Name:

Immune system

Title:

Crystal structure of c12c tcr-hlab2705-kk10-l6m

Structure:

Hla class i histocompatibility antigen, b-27 alpha chain. Chain: a. Fragment: unp residues 25-300. Synonym: mhc class i antigen b 27. Engineered: yes. Beta-2-microglobulin. Chain: b. Fragment: unp residues 21-119. Synonym: beta-2-microglobulin form pi 5.3.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-b, hlab. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: b2m, cdabp0092, hdcma22p. Synthetic: yes. Human immunodeficiency virus 1.

Resolution:

1.90Å R-factor: 0.190 R-free: 0.238

Authors:

S.Gras,P.G.Wilmann,J.Rossjohn

Key ref:

K.Ladell et al. (2013). A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells. Immunity, 38, 425-436. PubMed id: 23521884 DOI: 10.1016/j.immuni.2012.11.021

Date:

23-Jul-12 Release date: 20-Mar-13

Protein chain

P01889  (1B07_HUMAN) -  HLA class I histocompatibility antigen, B alpha chain from Homo sapiens

Seq: 362 a.a.

Struc: 276 a.a.*

Protein chain

P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens

Seq: 119 a.a.

Struc: 100 a.a.*

Protein chain

No UniProt id for this chain

Struc: 204 a.a.

Protein chain

No UniProt id for this chain

Struc: 250 a.a.

* PDB and UniProt seqs differ at 21 residue positions (black crosses)

DOI no: 10.1016/j.immuni.2012.11.021

Immunity 38:425-436 (2013)

PubMed id: 23521884

A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells.

K.Ladell, M.Hashimoto, M.C.Iglesias, P.G.Wilmann, J.E.McLaren, S.Gras, T.Chikata, N.Kuse, S.Fastenackels, E.Gostick, J.S.Bridgeman, V.Venturi, Z.A.Arkoub, H.Agut, D.J.van Bockel, J.R.Almeida, D.C.Douek, L.Meyer, A.Venet, M.Takiguchi, J.Rossjohn, D.A.Price, V.Appay.

ABSTRACT

No abstract given.