PDBsum entry 4g6w

Transferase

PDB id: 4g6w

Contents

Protein chain

270 a.a.

Ligands

PBX

SO4 ×2

Waters ×67

PDB id:

4g6w

Name:

Transferase

Title:

Human thymidylate synthase m190k with bound 4-bromobenzene-1,2,3-triol

Structure:

Thymidylate synthase. Chain: x. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: tyms, ts, ok/sw-cl.29. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.30Å R-factor: 0.224 R-free: 0.264

Authors:

L.R.Celeste,L.Lebioda

Key ref:

L.R.Celeste et al. Oxidation of cysteine 195 of huyman thymidylate synth purpurogallin. To be published, .

Date:

19-Jul-12 Release date: 24-Jul-13

Protein chain

P04818  (TYSY_HUMAN) -  Thymidylate synthase from Homo sapiens

Seq: 313 a.a.

Struc: 270 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.1.1.45 - thymidylate synthase.
• Pathway: Folate Coenzymes
• Reaction: dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP

Molecule diagrams generated from .mol files obtained from the KEGG ftp site