PDBsum entry 4fpt

Lyase/lyase inhibitor

PDB id: 4fpt

Contents

Protein chain

257 a.a.

Ligands

MBO

0VZ

GOL

DMS ×2

Metals

_ZN

Waters ×302

PDB id:

4fpt

Name:

Lyase/lyase inhibitor

Title:

Carbonic anhydrase ii in complex with ethyl (2z,4r)-2- (sulfamoylimino)-1,3-thiazolidine-4-carboxylate

Structure:

Carbonic anhydrase 2. Chain: a. Synonym: carbonate dehydratase ii, carbonic anhydrasE C, cac, carbonic anhydrase ii, ca-ii. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

0.98Å R-factor: 0.129 R-free: 0.158

Authors:

A.Di Pizio,A.Heine,G.Klebe

Key ref:

A.Di pizio et al. High resolution crystal structures of carbonic anhydr in complex with novel sulfamide binders. To be published, .

Date:

22-Jun-12 Release date: 03-Jul-13

Protein chain

P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2 from Homo sapiens

Seq: 260 a.a.

Struc: 257 a.a.

Enzyme reactions

• Enzyme class: E.C.4.2.1.1 - carbonic anhydrase.
• Reaction: hydrogencarbonate + H⁺ = CO2 + H2O
• Cofactor: Zn(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site