PDBsum entry 4fpb

Transferase

PDB id: 4fpb

Contents

Protein chains

899 a.a.

Ligands

BGC ×4

0WK ×4

CIT ×2

Metals

_NA ×4

Waters ×193

PDB id:

4fpb

Name:

Transferase

Title:

Crystal structure of recombinant human hexokinase type i with 1,5- anhydroglucitol 6-phosphate

Structure:

Hexokinase-1. Chain: a, b. Synonym: brain form hexokinase, hexokinase type i, hk i. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hk1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

3.00Å R-factor: 0.230 R-free: 0.256

Authors:

L.Shen,R.B.Honzatko

Key ref:

L.Shen et al. Inhibitor sites of unequal affinity linked by binding synergism in mutant forms of recombinant human hexoki type-I. To be published, .

Date:

21-Jun-12 Release date: 03-Jul-13

Protein chains

P19367  (HXK1_HUMAN) -  Hexokinase-1 from Homo sapiens

Seq: 917 a.a.

Struc: 899 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.1.1 - hexokinase.
• Reaction: a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H⁺

D-hexose + ATP (Bound ligand (Het Group name = BGC) corresponds exactly) = D-hexose 6-phosphate + ADP (Bound ligand (Het Group name = 0WK) matches with 93.75% similarity) + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site