PDBsum entry 4fos

Oxidoreductase

PDB id: 4fos

Contents

Protein chain

263 a.a.

Ligands

SKM

Waters ×100

PDB id:

4fos

Name:

Oxidoreductase

Title:

Crystal structure of shikimate dehydrogenase (aroe) q237a mutant from helicobacter pylori in complex with shikimate

Structure:

Shikimate dehydrogenase. Chain: a. Engineered: yes. Mutation: yes

Source:

Helicobacter pylori. Organism_taxid: 85962. Strain: 26695. Gene: aroe, hp_1249. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.72Å R-factor: 0.173 R-free: 0.199

Authors:

W.C.Cheng,T.J.Chen,W.C.Wang

Date:

21-Jun-12 Release date: 26-Dec-12

Protein chain

P56119  (AROE_HELPY) -  Shikimate dehydrogenase (NADP(+)) from Helicobacter pylori (strain ATCC 700392 / 26695)

Seq: 263 a.a.

Struc: 263 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.1.1.1.25 - shikimate dehydrogenase (NADP(+)).
• Pathway: Shikimate and Chorismate Biosynthesis
• Reaction: shikimate + NADP⁺ = 3-dehydroshikimate + NADPH + H⁺

shikimate + NADP(+) (Bound ligand (Het Group name = SKM) corresponds exactly) = 3-dehydroshikimate + NADPH + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site