PDBsum entry 4eb6

Structural protein/inhibitor

PDB id: 4eb6

Contents

Protein chains

433 a.a.

432 a.a.

132 a.a.

Ligands

GTP ×2

SO4 ×5

GDP ×2

VLB

Metals

_MG ×2

Waters ×31

PDB id:

4eb6

Name:

Structural protein/inhibitor

Title:

Tubulin-vinblastine: stathmin-like complex

Structure:

Tubulin alpha chain. Chain: a, c. Tubulin beta chain. Chain: b, d. Stathmin-4. Chain: e. Fragment: unp residues 49-189. Synonym: stathmin-like protein b3, rb3. Engineered: yes.

Source:

Ovis aries. Sheep. Organism_taxid: 9940. Domestic sheep,lambs,wild sheep. Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: stmn4. Expressed in: escherichia coli.

Resolution:

3.47Å R-factor: 0.215 R-free: 0.253

Authors:

F.M.Ranaivoson,B.Gigant,M.Knossow

Key ref:

F.M.Ranaivoson et al. (2012). Structural plasticity of tubulin assembly probed by vinca-domain ligands. Acta Crystallogr D Biol Crystallogr, 68, 927-934. PubMed id: 22868758

Date:

23-Mar-12 Release date: 01-Aug-12

Protein chains

D0VWZ0  (D0VWZ0_SHEEP) -  Tubulin alpha chain from Ovis aries

Seq: 451 a.a.

Struc: 433 a.a.*

Protein chains

D0VWY9  (D0VWY9_SHEEP) -  Tubulin beta chain from Ovis aries

Seq: 445 a.a.

Struc: 432 a.a.*

Protein chain

P63043  (STMN4_RAT) -  Stathmin-4 from Rattus norvegicus

Seq: 189 a.a.

Struc: 132 a.a.*

* PDB and UniProt seqs differ at 9 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B, C, D, E: E.C.?

Acta Crystallogr D Biol Crystallogr 68:927-934 (2012)

PubMed id: 22868758

Structural plasticity of tubulin assembly probed by vinca-domain ligands.

F.M.Ranaivoson, B.Gigant, S.Berritt, M.Joullié, M.Knossow.

ABSTRACT

No abstract given.