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PDBsum entry 4dz8
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protein ligands Protein-protein interface(s) links
Immune system PDB id
4dz8

 

 

 

 

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Contents
Protein chain
211 a.a.
Ligands
NAG-NAG-BMA-MAN-
NAG-MAN-NAG-FUC ×2
Waters ×436
PDB id:
4dz8
Name: Immune system
Title: Human igg1 fc fragment heterodimer
Structure: Ig gamma-1 chain c region. Chain: a. Fragment: unp residues 108-330. Engineered: yes. Ig gamma-1 chain c region. Chain: b. Fragment: unp residues 108-330. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ighg1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek. Expression_system_cell_line: hek
Resolution:
1.91Å     R-factor:   0.206     R-free:   0.237
Authors: P.Strop
Key ref: P.Strop et al. (2012). Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair. J Mol Biol, 420, 204-219. PubMed id: 22543237
Date:
29-Feb-12     Release date:   01-Aug-12    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P01857  (IGHG1_HUMAN) -  Immunoglobulin heavy constant gamma 1 from Homo sapiens
Seq:
Struc: 		399 a.a.
211 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 

 
J Mol Biol 420:204-219 (2012)
PubMed id: 22543237  
 
 
Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair.
P.Strop, W.H.Ho, L.M.Boustany, Y.N.Abdiche, K.C.Lindquist, S.E.Farias, M.Rickert, C.T.Appah, E.Pascua, T.Radcliffe, J.Sutton, J.Chaparro-Riggers, W.Chen, M.G.Casas, S.M.Chin, O.K.Wong, S.H.Liu, G.Vergara, D.Shelton, A.Rajpal, J.Pons.
 
  ABSTRACT  
 
No abstract given.

 

 

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