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PDBsum entry 4dq1
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PDB id:
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Transferase
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Title:
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Thymidylate synthase from staphylococcus aureus.
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Structure:
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Thymidylate synthase. Chain: a, b. Synonym: ts, tsase. Engineered: yes
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Source:
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Staphylococcus aureus. Organism_taxid: 158878. Strain: subsp. Aureus mu50. Gene: sav1427, thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.71Å
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R-factor:
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0.195
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R-free:
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0.252
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Authors:
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J.Osipiuk,J.Holowicki,R.Jedrzejczak,E.Rubin,K.Guinn,T.Ioerger, D.Baker,J.Sacchettini,A.Joachimiak,Midwest Center For Structural Genomics (Mcsg),Structures Of Mtb Proteins Conferring Susceptibility To Known Mtb Inhibitors (Mtbi)
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Key ref:
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J.Osipiuk
et al.
Thymidylate synthase from staphylococcus aureus..
To be published,
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Date:
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14-Feb-12
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Release date:
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21-Mar-12
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PROCHECK
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Headers
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References
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P67046
(TYSY_STAAM) -
Thymidylate synthase from Staphylococcus aureus (strain Mu50 / ATCC 700699)
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Seq:
Struc:
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318 a.a.
312 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.1.1.45
- thymidylate synthase.
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Pathway:
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Folate Coenzymes
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Reaction:
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dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP
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dUMP
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+
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(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate
Bound ligand (Het Group name = )
corresponds exactly
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=
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7,8-dihydrofolate
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+
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dTMP
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
