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PDBsum entry 4dpe
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Hydrolase/hydrolase inhibitor
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PDB id
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4dpe
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Contents |
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 _PT
×6
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 _ZN
×4
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 _CA
×6
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_CL
×2
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Structure of mmp3 complexed with a platinum-based inhibitor.
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Structure:
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Stromelysin-1. Chain: a, b. Fragment: unp residues 100-272. Synonym: sl-1, matrix metalloproteinase-3, mmp-3, transin-1. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp3, stmy1. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.96Å
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R-factor:
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0.184
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R-free:
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0.231
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Authors:
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B.D.Belviso,F.Arnesano,V.Calderone,R.Caliandro,G.Natile,D.Siliqi
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Key ref:
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B.D.Belviso
et al.
(2013).
Structure of matrix metalloproteinase-3 with a platinum-based inhibitor.
Chem Commun (camb),
49,
5492-5494.
PubMed id:
DOI:
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Date:
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13-Feb-12
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Release date:
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20-Feb-13
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PROCHECK
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Headers
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References
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P08254
(MMP3_HUMAN) -
Stromelysin-1 from Homo sapiens
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Seq:
Struc:
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477 a.a.
168 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.4.24.17
- stromelysin 1.
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Reaction:
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Preferential cleavage where P1', P2' and P3' are hydrophobic residues.
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Cofactor:
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Ca(2+); Zn(2+)
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DOI no:
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Chem Commun (camb)
49:5492-5494
(2013)
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PubMed id:
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Structure of matrix metalloproteinase-3 with a platinum-based inhibitor.
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B.D.Belviso,
R.Caliandro,
D.Siliqi,
V.Calderone,
F.Arnesano,
G.Natile.
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ABSTRACT
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An X-ray investigation has been performed with the aim of characterizing the
binding sites of a platinum-based inhibitor (K[PtCl3(DMSO)]) of matrix
metalloproteinase-3 (stromelysin-1). The platinum complex targets His224 in the
S1' specificity loop, representing the first step in the selective inhibition
process (PDB ID code ).
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Links
