PDBsum entry 4d3c

Protein binding

PDB id: 4d3c

Contents

Protein chains

137 a.a.

210 a.a.

209 a.a.

Waters ×22

PDB id:

4d3c

Name:

Protein binding

Title:

Crystal structure of the nk1 domain of hgf in complex with anti-hgf monoclonal antibody sfn68.

Structure:

Hepatocyte growth factor. Chain: a. Fragment: residues 23-210. Synonym: hepatopoietin-a, scatter factor, sf, nk1. Engineered: yes. Mutation: yes. Sfn68 fab. Chain: h. Sfn68 fab.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Other_details: rabbit/human chimeric antibody.

Resolution:

2.62Å R-factor: 0.269 R-free: 0.298

Authors:

Y.J.Kang,K.L.Kim,H.S.Cho,J.H.Chung

Key ref:

W.D.Tolbert et al. A mechanistic basis for converting a receptor tyrosin kinase agonist to an antagonist. To be published, .

Date:

21-Oct-14 Release date: 13-Jan-16

Protein chain

P14210  (HGF_HUMAN) -  Hepatocyte growth factor from Homo sapiens

Seq: 728 a.a.

Struc: 137 a.a.*

Protein chain

No UniProt id for this chain

Struc: 210 a.a.

Protein chain

P01834  (IGKC_HUMAN) -  Immunoglobulin kappa constant from Homo sapiens

Seq: 107 a.a.

Struc: 209 a.a.

Protein chain

U3KM01  (U3KM01_RABIT) -  Ig-like domain-containing protein from Oryctolagus cuniculus

Seq: 158 a.a.

Struc: 209 a.a.*

* PDB and UniProt seqs differ at 30 residue positions (black crosses)