PDBsum entry 4cl9

Transcription

PDB id: 4cl9

Contents

Protein chain

127 a.a.

Ligands

EDO

IES

Waters ×231

PDB id:

4cl9

Name:

Transcription

Title:

N-terminal bromodomain of human brd4 with i-bet295

Structure:

Bromodomain-containing protein 4. Chain: a. Fragment: n-terminal bromodomain, residues 44-168. Synonym: protein hunk1, brd4. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.40Å R-factor: 0.188 R-free: 0.199

Authors:

C.Chung,S.Atkinson

Key ref:

S.J.Atkinson et al. (2014). The structure based design of dual hdac/bet inhibitor novel epigenetic probes.. Medchemcomm, 5, 342.

Date:

13-Jan-14 Release date: 24-Dec-14

Protein chain

O60885  (BRD4_HUMAN) -  Bromodomain-containing protein 4 from Homo sapiens

Seq: 1362 a.a.

Struc: 127 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.?