PDBsum entry 3w1v

Lyase

PDB id: 3w1v

Contents

Protein chains

347 a.a.

Ligands

SO4 ×14

EPE

UDZ ×2

Metals

_NA

Waters ×385

PDB id:

3w1v

Name:

Lyase

Title:

Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in complex with inihibitor

Structure:

Capsular polysaccharide synthesis enzyme cap8e. Chain: a, b. Engineered: yes

Source:

Staphylococcus aureus. Organism_taxid: 158878. Strain: mu50. Gene: cape. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.10Å R-factor: 0.166 R-free: 0.207

Authors:

T.Miyafusa,J.M.Caaveiro,Y.Tanaka,K.Tsumoto

Key ref:

T.Miyafusa et al. Crystal structure of the capsular polysaccharide synthesizing protein cape of staphylococcus aureus.. Biosci rep, . PubMed id: 23611437

Date:

21-Nov-12 Release date: 12-Jun-13

Protein chains

A0A0H3JPH0  (A0A0H3JPH0_STAAM) -  UDP-glucose 4-epimerase from Staphylococcus aureus (strain Mu50 / ATCC 700699)

Seq: 342 a.a.

Struc: 347 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.5.1.3.2 - UDP-glucose 4-epimerase.
• Pathway: UDP-glucose, UDP-galactose and UDP-glucuronate Biosynthesis
• Reaction: UDP-alpha-D-glucose = UDP-alpha-D-galactose

UDP-alpha-D-glucose (Bound ligand (Het Group name = UDZ) matches with 79.07% similarity) = UDP-alpha-D-galactose

• Cofactor: NAD(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site