PDBsum entry 3vqg

Peptide binding protein

PDB id: 3vqg

Contents

Protein chain

85 a.a.

Ligands

VAL-THR-LEU-VAL

SO4

Waters ×118

PDB id:

3vqg

Name:

Peptide binding protein

Title:

Crystal structure analysis of the pdz domain derived from the tight junction regulating protein

Structure:

E3 ubiquitin-protein ligase lnx. Chain: a. Fragment: second pdz domain. Engineered: yes. C-terminal peptide from immunoglobulin superfamily member 5. Chain: b. Synonym: jam-4. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: lnx1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in mus musculus

Resolution:

1.35Å R-factor: 0.172 R-free: 0.207

Authors:

Y.Akiyoshi,D.Hamada,N.Goda,T.Tenno,H.Narita,A.Nakagawa,M.Furuse, M.Suzuki,H.Hiroaki

Key ref:

Y.Akiyoshi et al. Structural basis for down regulation of tight junctio pdz-Domain containing e3-Ubiquitin ligase. To be published, .

Date:

23-Mar-12 Release date: 27-Mar-13

Protein chain

O70263  (LNX1_MOUSE) -  E3 ubiquitin-protein ligase LNX from Mus musculus

Seq: 728 a.a.

Struc: 85 a.a.

Enzyme reactions

• Enzyme class: E.C.2.3.2.27 - RING-type E3 ubiquitin transferase.
• Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine