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PDBsum entry 3vff

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protein ligands Protein-protein interface(s) links
Hydrolase/hydrolase inhibitor PDB id
3vff

 

 

 

 

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Contents
Protein chains
265 a.a.
Ligands
CD8 ×4
PO4 ×3
Waters ×13
PDB id:
3vff
Name: Hydrolase/hydrolase inhibitor
Title: Blac e166a cdc-ome acyl-intermediate complex
Structure: Beta-lactamase. Chain: a, b, c, d. Synonym: penicillinase. Engineered: yes. Mutation: yes
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: blaa, blac, mt2128, mtcy49.07c, rv2068c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.78Å     R-factor:   0.246     R-free:   0.260
Authors: J.A.Mire,J.C.Sacchettini,Tb Structural Genomics Consortium (Tbsgc)
Key ref: H.Xie et al. Blac-Specific fluorogenic probes for rapid tuberculos detection. To be published, .
Date:
09-Jan-12     Release date:   19-Sep-12    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P9WKD3  (BLAC_MYCTU) -  Beta-lactamase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Seq:
Struc:
307 a.a.
265 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.3.5.2.6  - beta-lactamase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Penicillin Biosynthesis and Metabolism
      Reaction: a beta-lactam + H2O = a substituted beta-amino acid
      Cofactor: Zn(2+)

 

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