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PDBsum entry 3vbg
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Ligase/ligase activator
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PDB id
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3vbg
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PDB id:
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| Name: |
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Ligase/ligase activator
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Title:
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Structure of hdm2 with dimer inducing indolyl hydantoin ro-2443
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Structure:
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E3 ubiquitin-protein ligase mdm2. Chain: a, b, c, d. Fragment: unp residues 25-109. Synonym: double minute 2 protein, hdm2, oncoprotein mdm2, p53-binding protein mdm2. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: mdm2. Expressed in: escherichia coli. Expression_system_taxid: 511693.
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Resolution:
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2.80Å
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R-factor:
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0.184
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R-free:
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0.220
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Authors:
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C.M.Lukacs,C.A.Janson,B.J.Graves
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Key ref:
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B.Graves
et al.
(2012).
Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.
Proc Natl Acad Sci U S A,
109,
11788-11793.
PubMed id:
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Date:
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02-Jan-12
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Release date:
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27-Jun-12
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PROCHECK
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Headers
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References
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Q00987
(MDM2_HUMAN) -
E3 ubiquitin-protein ligase Mdm2 from Homo sapiens
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Seq:
Struc:
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491 a.a.
84 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.2.3.2.27
- RING-type E3 ubiquitin transferase.
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Reaction:
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S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6- ubiquitinyl-[acceptor protein]-L-lysine
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Proc Natl Acad Sci U S A
109:11788-11793
(2012)
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PubMed id:
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Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.
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B.Graves,
T.Thompson,
M.Xia,
C.Janson,
C.Lukacs,
D.Deo,
P.Di Lello,
D.Fry,
C.Garvie,
K.S.Huang,
L.Gao,
C.Tovar,
A.Lovey,
J.Wanner,
L.T.Vassilev.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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M.Wade,
Y.C.Li,
and
G.M.Wahl
(2012).
MDM2, MDMX and p53 in oncogenesis and cancer therapy.
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Nat Rev Cancer,
13,
83-96.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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Links
