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PDBsum entry 3v8x
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protein ligands Protein-protein interface(s) links
Membrane protein/metal transport PDB id
3v8x

 

 

 

 

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Contents
Protein chains
853 a.a.
676 a.a.
Ligands
NAG-NAG-BMA-MAN-
NAG-GAL-SIA-MAN-
NAG-GAL
NAG-NAG-BMA-MAN-
NAG-GAL-SIA-MAN-
NAG
C8E ×2
Waters ×204
PDB id:
3v8x
Name: Membrane protein/metal transport
Title: The crystal structure of transferrin binding protein a (tbpa) from neisserial meningitidis serogroup b in complex with full length human transferrin
Structure: Transferrin-binding protein 1. Chain: a. Engineered: yes. Mutation: yes. Serotransferrin. Chain: b. Synonym: transferrin, beta-1 metal-binding globulin, siderophilin. Engineered: yes
Source: Neisseria meningitidis serogroup b. Organism_taxid: 491. Gene: tbp1, nmb0461. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: tf, pro1400
Resolution:
2.60Å     R-factor:   0.211     R-free:   0.267
Authors: N.Noinaj,N.Easley,S.K.Buchanan
Key ref: N.Noinaj et al. (2012). Structural basis for iron piracy by pathogenic Neisseria. Nature, 483, 53-58. PubMed id: 22327295
Date:
23-Dec-11     Release date:   29-Feb-12    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q9K0U9  (TBP1_NEIMB) -  Transferrin-binding protein A from Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58)
Seq:
Struc: 		 
Seq:
Struc: 		915 a.a.
853 a.a.*
Protein chain
Pfam   ArchSchema ?
P02787  (TRFE_HUMAN) -  Serotransferrin from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		698 a.a.
676 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 

 
Nature 483:53-58 (2012)
PubMed id: 22327295  
 
 
Structural basis for iron piracy by pathogenic Neisseria.
N.Noinaj, N.C.Easley, M.Oke, N.Mizuno, J.Gumbart, E.Boura, A.N.Steere, O.Zak, P.Aisen, E.Tajkhorshid, R.W.Evans, A.R.Gorringe, A.B.Mason, A.C.Steven, S.K.Buchanan.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23142986 J.S.Woo, A.Zeltina, B.A.Goetz, and K.P.Locher (2012).
X-ray structure of the Yersinia pestis heme transporter HmuUV.
  Nat Struct Mol Biol, 19, 1310-1315.
PDB code: 4g1u
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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