 |
PDBsum entry 3v4t
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Transferase
|
|
|
Title:
|
|
E. Cloacae c115d mura liganded with unag
|
|
Structure:
|
|
Udp-n-acetylglucosamine 1-carboxyvinyltransferase. Chain: a, b, c, d, e, f, g, h. Synonym: enoylpyruvate transferase, udp-n-acetylglucosamine enolpyruvyl transferase, ept. Engineered: yes. Mutation: yes
|
|
Source:
|
|
Enterobacter cloacae. Organism_taxid: 550. Strain: atcc 13047 / dsm 30054 / nbrc 13535 / ncdc 279-56. Gene: ecl_04571, mura, murz. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
Resolution:
|
|
|
2.50Å
|
R-factor:
|
0.208
|
R-free:
|
0.271
|
|
|
Authors:
|
|
J.-Y.Zhu,Y.Yang,E.Schonbrunn
|
|
Key ref:
|
|
J.Y.Zhu
et al.
(2012).
Functional consequence of covalent reaction of phosphoenolpyruvate with UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA).
J Biol Chem,
287,
12657-12667.
PubMed id:
|
|
|
Date:
|
|
|
15-Dec-11
|
Release date:
|
07-Mar-12
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
P33038
(MURA_ENTCC) -
UDP-N-acetylglucosamine 1-carboxyvinyltransferase from Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCTC 10005 / WDCM 00083 / NCDC 279-56)
|
|
|
|
Seq:
Struc:
|
|
|
|
419 a.a.
419 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.2.5.1.7
- UDP-N-acetylglucosamine 1-carboxyvinyltransferase.
|
|
|
|
|
|
|
Pathway:
|
|
Peptidoglycan Biosynthesis (Part 1)
|
|
|
|
|
|
Reaction:
|
|
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-3- O-(1-carboxyvinyl)-alpha-D-glucosamine + phosphate
|
|
|
|
|
|
phosphoenolpyruvate
Bound ligand (Het Group name = )
matches with 40.00% similarity
|
+
|
UDP-N-acetyl-alpha-D-glucosamine
|
=
|
UDP-N-acetyl-3- O-(1-carboxyvinyl)-alpha-D-glucosamine
|
+
|
phosphate
|
|
|
|
|
|
|
|
|
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
|
| |
|
|
J Biol Chem
287:12657-12667
(2012)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Functional consequence of covalent reaction of phosphoenolpyruvate with UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA).
|
|
J.Y.Zhu,
Y.Yang,
H.Han,
S.Betzi,
S.H.Olesen,
F.Marsilio,
E.Schönbrunn.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Links
