PDBsum entry 3v4a

Transcription

PDB id: 3v4a

Contents

Protein chains

244 a.a.

11 a.a.

Ligands

PK1

SO4

Waters ×250

PDB id:

3v4a

Name:

Transcription

Title:

Structure of ar lbd with activator peptide and sarm inhibitor 2

Structure:

Androgen receptor. Chain: a. Fragment: unp residues 671-919. Synonym: dihydrotestosterone receptor, nuclear receptor subfamily 3 group c member 4. Engineered: yes. Androgen receptor. Chain: b. Fragment: unp residues 21-31.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ar, dhtr, nr3c4. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Resolution:

1.95Å R-factor: 0.172

Authors:

F.Nique,S.Hebbe,C.Peixoto,D.Annoot,J.-M.Lefrancois,E.Duval,L.Michoux, N.Triballeau,J.M.Lemoullec,P.Mollat,M.Thauvin,T.Prange,D.Minet, P.Clement-Lacroix,C.Robin-Jagerschmidt,D.Fleury,D.Guedin,P.Deprez

Key ref:

F.Nique et al. (2012). Discovery of diarylhydantoins as new selective androgen receptor modulators. J Med Chem, 55, 8225-8235. PubMed id: 22897611

Date:

14-Dec-11 Release date: 05-Sep-12

Protein chain

P10275  (ANDR_HUMAN) -  Androgen receptor from Homo sapiens

Seq: 920 a.a.

Struc: 244 a.a.

Protein chain

P10275  (ANDR_HUMAN) -  Androgen receptor from Homo sapiens

Seq: 920 a.a.

Struc: 11 a.a.

J Med Chem 55:8225-8235 (2012)

PubMed id: 22897611

Discovery of diarylhydantoins as new selective androgen receptor modulators.

F.Nique, S.Hebbe, C.Peixoto, D.Annoot, J.M.Lefrançois, E.Duval, L.Michoux, N.Triballeau, J.M.Lemoullec, P.Mollat, M.Thauvin, T.Prangé, D.Minet, P.Clément-Lacroix, C.Robin-Jagerschmidt, D.Fleury, D.Guédin, P.Deprez.

ABSTRACT

No abstract given.