PDBsum entry 3v2j

Lyase

PDB id: 3v2j

Contents

Protein chain

257 a.a.

Ligands

AZM

Metals

_ZN

Waters ×89

PDB id:

3v2j

Name:

Lyase

Title:

Effect of sucrose and glycerol as cryoprotectans, on the inhibition of human carbonic anhydrase ii

Structure:

Carbonic anhydrase 2. Chain: a. Synonym: carbonate dehydratase ii, carbonic anhydrasE C, cac, carbonic anhydrase ii, ca-ii. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.70Å R-factor: 0.141 R-free: 0.167

Authors:

M.Aggarwal,A.Mckenna

Key ref:

M.Aggarwal and a.mckenna Effect of sucrose and glycerol as cryoprotectans, On inhibition of human carbonic anhydrase ii. To be published, .

Date:

12-Dec-11 Release date: 26-Dec-12

Protein chain

P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2 from Homo sapiens

Seq: 260 a.a.

Struc: 257 a.a.

Enzyme reactions

• Enzyme class 2: E.C.4.2.1.1 - carbonic anhydrase.
• Reaction: hydrogencarbonate + H⁺ = CO2 + H2O
• Cofactor: Zn(2+)
• Enzyme class 3: E.C.4.2.1.69 - cyanamide hydratase.
• Reaction: urea = cyanamide + H2O

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site