PDBsum entry 3v2b

Transferase

PDB id: 3v2b

Contents

Protein chain

176 a.a.

Ligands

AR6

Waters ×96

PDB id:

3v2b

Name:

Transferase

Title:

Human poly(adp-ribose) polymerase 15 (artd7, bal3), macro domain 2 in complex with adenosine-5-diphosphoribose

Structure:

Poly [adp-ribose] polymerase 15. Chain: a. Fragment: macro domain 2. Synonym: parp-15, b-aggressive lymphoma protein 3. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: bal3, parp15. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.20Å R-factor: 0.176 R-free: 0.238

Authors:

T.Karlberg,M.Moche,C.H.Arrowsmith,H.Berglund,C.Bountra,R.Collins, A.M.Edwards,S.Flodin,A.Flores,S.Graslund,M.Hammarstrom,I.Johansson, A.Kallas,T.Kotenyova,A.Kotzcsh,P.Kraulis,T.K.Nielsen,P.Nordlund, T.Nyman,C.Persson,A.K.Roos,P.Schutz,M.I.Siponen,A.G.Thorsell, L.Tresaugues,S.Van Den Berg,J.Weigelt,M.Welin,M.Wisniewska, H.Schuler,Structural Genomics Consortium (Sgc)

Key ref:

A.H.Forst et al. (2013). Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains. Structure, 21, 462-475. PubMed id: 23473667 DOI: 10.1016/j.str.2012.12.019

Date:

12-Dec-11 Release date: 21-Dec-11

Supersedes:

3kh6

Protein chain

Q460N3  (PAR15_HUMAN) -  Protein mono-ADP-ribosyltransferase PARP15 from Homo sapiens

Seq: 678 a.a.

Struc: 176 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.4.2.- - ?????

DOI no: 10.1016/j.str.2012.12.019

Structure 21:462-475 (2013)

PubMed id: 23473667

Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains.

A.H.Forst, T.Karlberg, N.Herzog, A.G.Thorsell, A.Gross, K.L.Feijs, P.Verheugd, P.Kursula, B.Nijmeijer, E.Kremmer, H.Kleine, A.G.Ladurner, H.Schüler, B.Lüscher.

ABSTRACT

No abstract given.