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PDBsum entry 3v2a
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Hormone/signaling protein
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PDB id
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3v2a
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PDB id:
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Hormone/signaling protein
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Title:
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Vegfr-2/vegf-a complex structure
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Structure:
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Vascular endothelial growth factor receptor 2. Chain: r. Fragment: unp residues 1-764. Synonym: vegfr-2, fetal liver kinase 1, flk-1, kinase insert domain receptor, kdr, protein-tyrosine kinase receptor flk-1. Engineered: yes. Vascular endothelial growth factor a. Chain: a. Fragment: unp residues 27-140.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: flk1, kdr, vegfr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: vegf, vegf-a, vegfa. Expressed in: pichia pastoris. Expression_system_taxid: 4922
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Resolution:
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3.20Å
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R-factor:
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0.247
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R-free:
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0.301
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Authors:
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M.S.Brozzo,V.-M.Leppanen,F.K.Winkler,K.Ballmer-Hofer
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Key ref:
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M.S.Brozzo
et al.
(2012).
Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization.
Blood,
119,
1781-1788.
PubMed id:
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Date:
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12-Dec-11
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Release date:
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18-Jan-12
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PROCHECK
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Headers
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References
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Enzyme class:
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Chain R:
E.C.2.7.10.1
- receptor protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Blood
119:1781-1788
(2012)
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PubMed id:
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Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization.
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M.S.Brozzo,
S.Bjelić,
K.Kisko,
T.Schleier,
V.M.Leppänen,
K.Alitalo,
F.K.Winkler,
K.Ballmer-Hofer.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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K.Verstraete,
and
S.N.Savvides
(2012).
Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases.
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Nat Rev Cancer,
12,
753-766.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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Links
